Some things are counterintuitive. I would never expect the results of the Frail AF. Always had a feeling that DOACs would be better in multimorbidity patients.

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Sep 20Liked by Andrew J Foy

Hope you guys do the CAC podcast soon. My wife’s doctor had her get one and I foresee mine doing the same in the future. Would like to know your interpretation of the data.


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Thank you very much for this. What do you say then to the 90 year old woman who is paying $800 a year in order to take Xarelto, and the 87-year-old who similarly pays for Eliquis? This is my mother, of course, and my husband’s father. These expenses represent no small chunk of the fixed income of these elders and I’m wondering what big Pharma might be willing to do in order to keep the elders on the DOACS after this paper gets widely dispersed.

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Sep 19Liked by Andrew J Foy

Thanks for an excellent discussion.

The de novo frail pt with new AF is the (or at least one) big unanswered question. From a purist POV, Frail AF is silent on this. But it sure gives you pause. Esp when, as you note, the foundational DOAC trials would’ve excluded such pts. OTOH, this was a trial of pts stable on VKA, so it would seem to have already selected for people LESS likely to bleed than the average frail pt. If DOACs cause more bleeding in this selected group....you “would think” it would cause even more in an unselected frail cohort. But on the third hand, maybe VKAs would cause even MORE bleeding in such an unselected cohort.

I find this to be the most difficult aspect of EBM: when you try to extrapolate study results beyond the exact study population.

And this leads to my distaste for current landscape of “guidelines”: they take data from these nicely manicured cohorts....and suggest/demand that you apply it without thought to everyone and their kitchen sink. Even if you accept the internal validity of the foundational studies, the presumption of universal external validity is, IMO, completely without merit.

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